Steroids | 2019
Screening, preparation and characterization of diosgenin versatile solvates
Abstract
HIGHLIGHTSThree new crystal solvates including methanol, DMF, and DMAC solvatomorphs of diosgenin were crystallized and characterized.The role and function of solvents have been elucidated.The solvent‐replacement method has been used to prepare the desirable crystalline form. ABSTRACT Solvatomorphism occurred in diosgenin solvates. A series of solvates including DMSO, DMF, DMAC, Methanol of diosgenin were obtained and crystallized in order to compare their structures and properties in the solid state. Single‐crystal X‐ray diffraction was used to analyze the crystal structures and the solvent types and the stoichiometric ratio of the diosgenin solvates. Hirshfeld surface analyses, especially dnorm surface and fingerprint plots, were used to determine intermolecular interactions in the crystal structure. Powder X‐ray diffraction, differential scanning calorimetry, thermogravimetric, Fourier transform Infrared spectroscopy were all used to characterize the diosgenin solvates. And the solvates transformation have been reported for the first time.