Photoredox catalytic cascade radical addition/aromatization of methylene-2-oxazolines: Mild access to C(sp3)-difluoro-oxazole derivatives

Abstract

Abstract Difluoroalkylated oxazoles were prepared from methylene-2-oxazolines (MOs) and difluoroalkylating reagents via a photoredox strategy. This reaction includes tandem radical addition and subsequent aromatization steps, resulting in 19 difluorinated oxazole derivatives with diverse functionalities and excellent reaction selectivity in the presence of multiple reactivity pathways.