Early ADAMTS13 testing associates with pre-eclampsia occurrence in antiphospholipid syndrome.

Abstract

INTRODUCTION\nWomen with obstetric antiphospholipid syndrome (oAPS) still develop placental diseases, mainly pre-eclampsia (PEcl), which diagnosis is associated with reduced ADAMTS13 levels. Testing ADAMTS13 in newly pregnant oAPS may provide evidence for risk stratification.\n\n\nMATERIALS AND METHODS\nWe retrospectively investigated the prognostic value of ADAMTS13 activity, antigen and antibodies on stored plasma samples obtained prior to beginning low-molecular weight heparin-low dose aspirin treatment in 513 oAPS women.\n\n\nRESULTS\nSome women had evidences of early positive ADAMTS13 antibodies and low ADAMTS13 activity:antigen ratio, suggestive of ADAMTS13 dysfunction. Women with a subsequent PEcl had higher ADAMTS13 antibodies (p\xa0<\xa00.0001), and lower ADAMTS13 activity and activity:antigen ratios (p\xa0<\xa00.0001). In multivariate analysis, these markers were significant risk factors for PEcl and for the most devastating PEcl subgroups (early-onset PEcl, severe PEcl, PEcl with no living child after 28\xa0days). ADAMTS13-related markers showed acceptable discrimination power to predict clinical events, particularly for ADAMTS13 activity:antigen ratio in predicting PEcl cases with no living child after 28\xa0days (AUC: 0.844 (0.712-0.974), p\xa0<\xa00.0001), with excellent negative predictive value (0.990).\n\n\nCONCLUSIONS\nThe characterization of ADAMTS13 in newly pregnant women with oAPS depicts the risk of PEcl occurrence. ADAMTS13 might help identify pregnant women with oAPS not requiring escalating treatment strategies to prevent PEcl.