Research Progress on the Protection and Detoxification of Phytochemicals against Aflatoxin B1-Induced Liver Toxicity.

Abstract

sAflatoxin B1 (AFB1) is a potent hepatotoxic toxin, which can cause hepatitis, cirrhosis, and liver immunological damage. It has been involved in the etiology of human hepatocellular carcinoma. AFB1 can cause oxidative stress in the body s metabolism process, and then cause cytotoxicity, such as apoptosis and DNA damage. Scientific research has discovered that phytochemicals can induce the detoxification pathway of AFB1 through its biotransformation, thereby reducing the damage of AFB1 to the human body. In clinical treatment, certain phytochemicals have been effectively used in the treatment of liver injury due to the advantages of multiple targets, multiple pathways, low toxicity and side effects. Therefore, the article summarizes the toxic mechanism of AFB1-induced hepatoxicity, and the related research progress of phytochemicals for preventing and treating its cytotoxicity and genotoxicity. We also look forward to the existing problems and application prospects of phytochemicals in the pharmaceutical industry, in order to provide theoretical reference for the prevention and treatment of AFB1 poisoning in future research work.