Cross-species comparison of CAR-mediated procarcinogenic key events in a 3D liver microtissue model

Abstract

Highlights • The first demonstration of phenobarbital-induced hepatocyte proliferation in 3D liver microtissue models.• Integration of quantitative histopathology data with genomics (transcriptomics/proteomics).• In vitro cross-species risk assessment.• CAR-mediated mode of action.• Quantitative histopathology of 3D microtissues.