Tailoring the size of ultrasound responsive lipid-shelled nanodroplets by varying production parameters and environmental conditions

Abstract

Highlights • Increasing the volumetric concentration of PFP led to an increase in the size of lipid-coated PFP NDs.• Increasing sonication intensity and time led to a decrease in ND size.• The ND coating layer can be labelled with lipophilic fluorophores without affecting the overall ND size.• NDs were stable at 4 °C for one week, and at 37 °C for 110 min.• Ultrasound (0.5 MHz, 2–4 MPa) caused vaporisation of NDs within a tissue-mimicking phantom.