An online decision tree for vaccine efficacy trial design during infectious disease epidemics: The InterVax-Tool

Abstract

Highlights • Phase 3 vaccine efficacy trial design during outbreaks and emergencies is challenging.• InterVax-Tool (vaxeval.com) is a structured decision-support tool for trial design.• Optimal design must include epidemiological, statistical, ethical, and logistical difficulties.• Navigating these issues in real-time requires tools to assist in decision-making.• Dynamic guidance, note taking, and tailored choices are key to good user engagement.