Visual surround suppression in people with epilepsy correlates with attentional-executive functioning, but not with epilepsy or seizure types

Abstract

PURPOSE\nFollowing reports that an index of visual surround suppression (SI) may serve as a biomarker for an imbalance of cortical excitation and inhibition in different psychiatric and neurological disorders including epilepsy, we evaluated whether SI is associated with seizure susceptibility, seizure spread, and inhibitory effects of antiseizure medication (ASM).\n\n\nMETHODS\nIn this prospective controlled study, we examined SI with a motion discrimination task in people with genetic generalized epilepsy (GGE) and focal epilepsy with and without focal to bilateral tonic-clonic seizures. Cofactors such as GABAergic ASM, attentional-executive functioning, and depression were taken into account.\n\n\nRESULTS\nData of 45 patients were included in the final analysis. Suppression index was not related to epilepsy or seizure type, GABAergic ASM treatment or mood. However, SI correlated with attentional-executive functioning (r\u202f=\u202f0.32), which in turn was associated with ASM load (r\u202f=\u202f-0.38). Repeated task administration (N\u202f=\u202f7) proved a high stability over a one-week interval (rtt\u202f=\u202f0.89).\n\n\nCONCLUSIONS\nOur results do not support the hypothesis that SI is a reliable biomarker for mechanisms related to inhibition of seizure spread or seizure frequency, i.e., it does not seem to reflect inhibitory capacities in epilepsy. Likewise, SI did not differentiate GGE from focal epilepsy, nor was it influenced by ASM load or mode of action. Thus, in epilepsy, no added value of including SI to routine diagnostics can be concluded.