Telencephalic regulation of the HPA axis in birds

Abstract

The hypothalamo-pituitary-adrenal (HPA) axis is one of the major output systems of the vertebrate stress response. It controls the release of cortisol or corticosterone from the adrenal gland. These hormones regulate a range of processes throughout the brain and body, with the main function of mobilizing energy reserves to improve coping with a stressful situation. This axis is regulated in response to both physical (e.g., osmotic) and psychological (e.g., social) stressors. In mammals, the telencephalon plays an important role in the regulation of the HPA axis response in particular to psychological stressors, with the amygdala and part of prefrontal cortex stimulating the stress response, and the hippocampus and another part of prefrontal cortex inhibiting the response to return it to baseline. Birds also mount HPA axis responses to psychological stressors, but much less is known about the telencephalic areas that control this response. This review summarizes which telencephalic areas in birds are connected to the HPA axis and are known to respond to stressful situations. The conclusion is that the telencephalic control of the HPA axis is probably an ancient system that dates from before the split between sauropsid and synapsid reptiles, but more research is needed into the functional relationships between the brain areas reviewed in birds if we want to understand the level of this conservation.