Evaluation of the penetrating ability of a perspective copper-containing drugs into cells using an electrochemical nanocapillary-based sensor

Abstract

Evaluation of the effectiveness of perspective drugs, as well as the study of their pharmacokinetics, has been one of the priority tasks at the stage of pre-clinical drug trials (Vaneev et al., 2020). In recent years, many copper-containing drugs have been developed since they have a high antimicrobial, antituberculosis, anti-malarial, antifungal and anti-inflammatory activity. However, in most cases various biological activity tests are carried out by expensive, high invasive (AAS, ICP-MS etc.), or difficult to synthesize and often low-precise (fluorescent labels) analysis methods. Thus, it difficult to understand the effect of drugs on living biological systems.