Progressive Supranuclear Palsy-like Syndrome from Possible Cerebral Amyloid Angiopathy.

Abstract

Progressive supranuclear palsy (PSP) is an atypical parkinsonian syndrome comprising of supranuclear vertical gaze palsy, pseudobulbar affect, postural instability, along with cognitive decline. Progressive supranuclear palsy is a neurodegenerative tauopathy. However, there are several conditions that can clinically mimic PSP presentation. New diagnostic criteria were developed by the International Parkinson and Movement Disorders Society (MDS) to improve the sensitivity and specificity for diagnosis of PSP/PSP variants. We report a case of an atypical PSP and emphasize the approach to PSP and other PSP-like presentations. A 75-year-old right-handed male presented with a 5-yearhistory of slow progressive parkinsonism with gait difficulty and falls in the absence of tremor. He also had slow progressive