Europium Hydroxide Nanorods (EHNs) Ameliorate Isoproterenol-Induced Myocardial Infarction: An in Vitro and in Vivo Investigation

Abstract

Cardiovascular diseases (CVDs) are one of the leading causes of global morbidity and mortality. Among these, the ischemic heart disease (IHD) or coronary artery disease (CAD) accounts for the major deaths due to CVDs. Several approaches followed to treat the ischemic heart diseases are limited due to various adverse effects and cost of treatment. Recently, nanotechnology has revolutionized the field of biomedical research by introducing various technologies to improve the health care, using a nanomedicine approach. In this context, our group has well-established the europium hydroxide nanorods (EHNs), which promote the formation of new blood vessels (angiogenesis) through reactive oxygen species (ROS) and nitric oxide (NO)-mediated signaling pathways. Further, these pro-angiogenic nanorods were also reported to exhibit a mild to nontoxic nature toward mammalian cells and mouse models. Henceforth, in the present study, myocardial ischemia (MI) was created in Wistar rats using isoproterenol (ISO), a well-es...