Prussian Blue Analogue Islands on BiOCl-Se Nanosheets for MR/CT Imaging-Guided Photothermal/Photodynamic Cancer Therapy

Abstract

Precision therapy combines the advantages of multimodal imaging and a synergistic treatment, which can provide higher therapeutic efficacy and a more rigorous diagnosis than solitary imaging or ordinary therapy. In this research, we synthesized innovative Se-doped BiOCl nanosheets (Se-BiOCl) via a solvothermal method. Then, islands of Prussian blue analogues (PBA) Bi4[Fe(CN)6]3 were loaded on the Se-BiOCl nanosheets via surface ion-exchange reactions to obtain the Se-BiOCl/PBA composite nanosheets. The successful integration of PBA made progressive T1- and T2-weighted magnetic resonance imaging (MRI) possible. In addition, the advanced computed tomography (CT) capabilities matched the high X-ray attenuation coefficient of Bi, thereby realizing multimodal imaging for accurate diagnoses. The strong absorbance in the near-infrared range provided by PBA offers high antitumor efficacy for photothermal therapy (PTT). In addition, with the doping of Se, the band gap of Se-BiOCl was adjusted from 387 nm (BiOCl) t...