Organic Process Research & Development | 2019
Systematic Optimization of a Robust Telescoped Process for a BTK Inhibitor with Atropisomer Control by High-Throughput Experimentation, Design of Experiments, and Linear Regression
Abstract
The development of a telescoped process for the API step in the route to a reversible inhibitor of BTK is reported. Although a robust and effective reaction and crystallization was previously imple...