0D/2D Coordination Complexes: Magnetic Studies, Protection, and Mechanism against Ischemic Myocardial Damage by Reducing the Activation of the PI3K/Akt Signaling Pathway

Abstract

The synthesis of two new coordination compounds was carried out by applying 4-(3-carboxyphenyl)picolinic acid (H2cppa) as building units under the hydrothermal reaction conditions, whose chemical formulae are [Cu(Hcppa)2(H2O)2]·2H2O (1) and [Cu(μ3-cppa)(H2O)2] (2). The analysis of structures suggested that 1 featured a discrete molecular structure, which was extended into the three-dimensional supramolecular network with the topology of pcu topology, whereas complex 2 showed a two-dimensional layered network with the fes topology. The magnetic performances of the two synthesized compounds reveal antiferromagnetic coupling between consecutive metal ions. Their application values on ischemic myocardial damage were assessed, and the detailed mechanism of the synthetic complexes was also investigated. The Elabscience Annexin V detection kit was used in this research to determine the percentage of apoptotic cardiomyocytes after different complex treatments. In addition, the relative expression of PI3K/Akt in the myocardium after the application of the compound was determined using the real-time reverse transcription polymerase chain reaction assay.