Disinfection of dental loupes

Abstract

There is no evidence to suggest that baseline detection of periodontopathogenic bacteria should be used as a criterion for prescribing adjunctive antibiotics. This paper considered the clinical benefit in periodontitis patients taking adjunctive systemic antimicrobials to non-surgical therapy, depending on pre-treatment detection of periodontopathogenic bacteria. A search was conducted for randomised controlled trials reporting clinical outcomes following adjunctive antibiotic for patients divided by baseline microbiological profiles. Four studies were suitable for a fixed effects two-stage individual participant meta-analysis adjusted for baseline data. Collectively, adjunctive Amoxicillin and Metronidazole yielded superior clinical results (measured as reduction of PPDs) compared to placebo. No significant differences were detected for the effect of adjunctive antibiotics by detection of A. actinomycetemcomitans on PPDs ≥ 5 mm or other clinical outcomes.