Association between blood pressure variability and the short-term outcome in patients with acute spontaneous subarachnoid hemorrhage

Abstract

The association between the fluctuation in blood pressure (BP) and the early outcomes of patients with subarachnoid hemorrhage (SAH) remains unclear. Our study aimed to evaluate the value of blood pressure variability (BPV) for predicting the short-term outcomes of patients with acute spontaneous SAH. We collected data from 303 patients hospitalized for acute spontaneous SAH. BP values were recorded at admission and subsequently every 2\u2009h during the initial 24\u2009h of hospitalization. BPV was determined as the standard deviation (SD), the difference between the maximum and the minimum (ΔBP), the coefficient of variation (CV), and successive variation (SV). The outcome at discharge was assessed according to the Glasgow Outcome Scale (GOS). The association between BPV and the outcome was identified by multivariable analysis. The findings showed that the parameters of systolic BPV were independently associated with the outcome in a graded fashion. The odds ratios (OR) for the highest tertiles were as follows: SD 13.9 (95% confidence interval [CI], 4.8–40.4), ΔBP 4.4 (95% CI, 1.6–11.9), CV 16.4 (95% CI, 5.6–48.8), SV 15.8 (95% CI, 5.3–46.9). However, there was no association between a poor outcome and diastolic BPV (all p\u2009>\u20090.05). In conclusion, systolic BPV within the first 24\u2009h after admission was independently associated with the outcomes in SAH patients; the greater the variability was, the worse the outcome.