Cryo-EM structure of AVP–V2 receptor complex

Abstract

The antidiuretic hormone arginine–vasopressin (AVP) forms a signalling complex with the vasopressin V2 receptor (V2R) and the Gs protein to promote water reabsorption in the kidney. Now, Bous and colleagues report the cryoelectron microscopy (cryoEM) structure of the AVP–V2R–Gs complex. Analysis of two ternary complex structures revealed distinct agonist and G protein binding modes, and provided insights into the mechanisms by which specific V2R mutations might affect V2R activity and Gs coupling, resulting in distinct Xlinked genetic diseases: congenital nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriate antidiuresis.