Tau inclusion turnover could be a target

Abstract

Tau inclusions are dynamic structures that turnover every few weeks, according to new research. Croft et al. used longterm optical pulse labelling to study the formation of tau inclusions in organotypic brain slice culture models. Tau inclusions initially formed within hours to a few days but were then renewed regularly with an initial halflife of ~1 week, which lengthened to ~3 weeks over time. The finding raises the possibility of therapeutic strategies that involve interruption of the renewal process to prevent further formation of tau inclusions.