Efficacy and safety of human papillomavirus vaccination in HIV-infected patients: a systematic review and meta-analysis

Abstract

The prophylactic vaccines available to protect against infections by HPV are well tolerated and highly immunogenic. People with HIV have a higher risk of developing HPV infection and HPV-associated cancers due to a lower immune response, and due to viral interactions. We performed a systematic review of RCTs to assess HPV vaccines efficacy and safety on HIV-infected people compared to placebo or no intervention in terms of seroconversion, infections, neoplasms, adverse events, CD4+ T-cell\xa0count and HIV viral load. The vaccine-group showed a seroconversion rate close to 100% for each vaccine and a significantly higher level of antibodies against HPV vaccine types, as compared to the placebo group (MD\u2009=\u20094333.3, 95% CI 2701.4; 5965.1 GMT EL.U./ml for HPV type 16 and MD\u2009=\u20091408.8, 95% CI 414.8; 2394.7 GMT EL.U./ml for HPV type 18). There were also no differences in terms of severe adverse events (RR\u2009=\u20090.6, 95% CI 0.2; 1.6) and no severe adverse events (RR\u2009=\u20090.6, 95% CI 0.9; 1.2) between vaccine and placebo groups. Secondary outcomes, such as CD4\u2009+\u2009T-cell count and HIV viral load, did not differ between groups (MD\u2009=\u200914.8, 95% CI −\xa035.1; 64.6 cells/µl and MD\u2009=\u20090.0, 95% CI −\xa00.3; 0.3 log10 RNA copies/ml, respectively). Information on the remaining outcomes was scarce and that did not allow us to combine the data. The results support the use of the HPV vaccine in HIV-infected patients and highlight the need of further RCTs assessing the effectiveness of the HPV vaccine on infections and neoplasms.