Author Correction: DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis

Abstract

“Of 247 patients who underwent hepatectomy between January 2009 and June 2019 at Kyoto University Hospital, 17 patients with HCC were selected and subjected to RNAseq. Out of 34 patients who underwent living-donor liver transplantation with a diagnosis of liver cirrhosis and decompensated liver failure between January 2014 and October 2015, nine cases were randomly selected and 15 RN tissues were manually collected from the explanted liver sections. For control samples, we used existing RNAseq data of seven normal liver tissues provided by living donors for liver transplantation, which were collected in our previous study42. Written informed consent was obtained from all the patients and donors mentioned above. In addition, 40 RNAseq datasets of HCV-positive HCCs were obtained from the Japanese cohort of International Cancer Genome Consortium (ICGC) database (Project code, LIRI-JP). The details are described in Supplementary Materials and Methods. The downloaded data on chronic hepatitis were analyzed on the same pipeline as that used for our hospital’s data on HCC, RN and normal liver samples. This research conformed to the provisions of the Declaration of Helsinki. The study protocol was approved by the ethics committee of Kyoto University.”