Regioselective, copper(i)-catalyzed, tandem sulfonylation-cyclization of 1,5-dienes with sulfonyl chlorides

Abstract

A copper(I)-catalyzed sulfonylation-cyclization of 1,5-dienes with sulfonyl chlorides was developed. This transformation demonstrated a broad substrate scope and presented excellent regioselectivity after radical addition and subsequent deprotonation to form the derivatized 1,5-dihydro-2H-pyrrol-2-one scaffold in one pot.