Photo-oxygenation inhibits tau amyloid formation.

Abstract

Tau amyloid formation and deposition are responsible for the onset of Alzheimer s disease. In particular, the seeding activity of the tau protein plays an important role in the spreading of tau pathology via its propagation in the human brain. Here we demonstrate that catalytic photo-oxygenation markedly suppresses tau seeding activity, resulting in the inhibition of amyloid formation, both in vitro and in cultured cells.