Photocatalyst-free decarboxylative aminoalkylation of imidazo[1,2-a]pyridines with N-aryl glycines enabled by visible light

Abstract

A novel, green and efficient visible-light-promoted decarboxylative aminoalkylation reaction of imidazo[1,2-a]pyridines with N-aryl glycines has been described. A diverse range of imidazo[1,2-a]pyridines undergoes the reaction well with N-aryl glycines to afford the desired corresponding products in good to high yields. This photocatalyst-free decarboxylative protocol not only manifests high regio-selectivity to biologically important imidazo[1,2-a]pyridines, but also avoids the use of expensive photosensitizers and extra additives, which makes this decarboxylative coupling more practical and sustainable.