Current Development of the Applications of Polymers in Gene Delivery

Abstract

Gene delivery is one of the most important and efficient therapy methods for treating diseases, especially genetic diseases that challenge conventional treatment methods. However, to be efficient, gene delivery has a few requirements for the polymers to be applicable, including the reduction of cytotoxicity, the improvement of transfection efficiency, and the elimination of off-target effects. In this study, the common polymers applied in gene delivery is discussed in depth, regarding such requirements, as well as some of the limitations and potential improvements in gene delivery.