[Risk Factors for Permanent Postoperative Hypoparathyreoidism].

Abstract

BACKGROUND\nPermanent postoperative hypoparathyreoidism remains the most frequent complication after total thyreoidectomy with severe long-term morbidity, impairment of quality of life and economic implications.\n\n\nOBJECTIVE\nIdentification of risk factors for permanent postoperative hypoparathyreoidism.\n\n\nMATERIAL AND METHODS\n420 patients received total thyreoidectomy in our endocrine centre between 08/2012 und 08/2014, of whom 382 were included in the study. 117 patients underwent a follow-up investigation between 8 and 32 months postoperatively.\n\n\nRESULTS\nWe determined a low parathyroid hormone level on postoperative day 1, non-application of a drain and a prolonged postoperative hospital stay as being associated with permanent postoperative hypoparathyreoidism. No association was found between postoperative hypoparathyroidism and autotransplantation of a parathyroid gland. Associations were strong but not significant.\n\n\nDISCUSSION\nWe identified associated factors for permanent postoperative hypoparathyreoidism. Larger multicentre studies should be performed for validation as possible relevant risk factors. Knowledge of risk factors might help to avoid this complication and to manage close follow-up and therapy in patients affected.