Short versus standard esophageal myotomy in achalasia patients: a systematic review and meta-analysis of comparative studies

Abstract

Background and study aims\u2002 Despite the clinical efficacy of peroral endoscopic myotomy (POEM), postoperative symptomatic gastroesophageal reflux disease (GERD) remains a major concern. While it is known that length of the gastric myotomy affects postoperative GERD, the clinical relevance of variation in esophageal myotomy length is not well known. We performed a systematic review and meta-analysis of studies comparing outcomes of short versus standard myotomy length in patients with achalasia. Patients and methods\u2002 We searched multiple databases from inception through November 2020 to identify studies that reported on outcomes of achalasia patients who underwent short compared with standard esophageal myotomy. Meta-analysis was performed to determine pooled odds ratio (OR) of clinical success, GERD outcomes, and adverse events with the two techniques. Results\u2002 5 studies with 474 patients were included in the final analysis (short myotomy group 214, standard myotomy group 260). There was no difference in clinical success (OR 1.17, 95\u200a% confidence interval [CI] 0.54–2.52; I2 0\u200a%; P \u200a=\u200a0.69), postoperative symptomatic GERD (OR 0.87, 95\u200a%CI 0.44–1.74; I2 29\u200a%; P \u200a=\u200a0.70), and overall adverse events (OR 0.52, 95\u200a%CI 0.19–1.38; I2 40\u200a%; P \u200a=\u200a0.19), between the two groups. Incidence of postoperative erosive esophagitis as determined by endoscopy was lower in the short myotomy group (OR 0.50, 95\u200a%CI 0.24–1.03; I2 0\u200a%; P \u200a=\u200a0.06). Conclusion\u2002 Our analysis showed that performing POEM with short esophageal myotomy in achalasia was as safe and effective as standard myotomy, with lower incidence of postoperative erosive esophagitis.