Nomogram prediction for the involution of the ablation zone after radiofrequency ablation treatment in patients with low-risk papillary thyroid carcinoma.

Abstract

OBJECTIVES\nTo construct a prognostic nomogram to predict the involution of the ablation zone for patients with low-risk papillary thyroid carcinoma (PTC) who underwent radiofrequency ablation (RFA) treatment.\n\n\nMETHODS\nData from 204 patients with low-risk PTC without extrathyroidal extension or cervical lymph node or distant metastasis who underwent RFA treatment were collected from January 2018 to January 2019. Clinicopathological and imaging characteristics were analyzed. The prognostic factors associated with the involution of the ablation zone within 12\u2009months after RFA were identified by logistic analysis, and the nomogram was established. Calibration curve and decision curve analysis were used to evaluate the nomogram performance.\n\n\nRESULTS\nOf the 204 patients included in this study, the ablation zone in 78 (38%) patients did not completely disappear in the 12\u2009months after RFA. Four variables, including sex (odds ratio [OR], 3.303; 95% confidence interval [CI], 1.418-8.418; p\u2009=\u20090.008), age (OR, 1.045; 95% CI, 1.012-1.081; p\u2009=\u20090.009), calcification size (OR, 1.666; 95% CI, 1.041-2.701; p\u2009=\u20090.035), and RFA energy (OR, 2.902; 95% CI, 1.333-6.683; p\u2009=\u20090.009), were found to be closely associated with ablation zone non-disappearance at 12\u2009months after RFA by multivariate analysis. A nomogram model was constructed, and its accuracy was well validated (C-index = 0.787).\n\n\nCONCLUSIONS\nThis study constructed and validated a risk model that could accurately predict the involution of the ablation zone after RFA for patients with PTC. This could provide clinicians with useful resource to guide patient counseling regarding tumor prognosis after RFA.