The Journal of asthma : official journal of the Association for the Care of Asthma | 2021
Identifiying wheezing phenotypes in a pediatric Turkish cohort.
Abstract
Objective: Characterization of wheezing phenotypes in children might help to identify the underlying mechanisms through which asthma occurs. In our study we aimed to describe wheezing phenotypes in Turkish children and to identify risk factors according to phenotypes.Methods: 651 wheezy children were evaluated and 5 wheezing phenotypes were described according to age of onset, atopy and persistance at 6\u2009years of age and risk factors were identified.Results: Distrubition of wheezing phenotypes was: transient early wheeze (TEW)(%34,9) non-atopic wheeze (NAW) (%18), atopic wheeze (AW) (%22,3), intermediate onset wheeze (IOW) (%11,1), late onset wheeze(LOW) (%11,7). LOW, AW and IOW were associated with, father s, sibling s and family s atopy (p:0.001) whereas LOW and AW were associated with mother s asthma and atopy as well as family s asthma (p\u2009<\u20090.05). Atopic dermatitis and allergic rhinitis were common of patients with LOW, AW and IOW (p\u2009<\u20090.05). İnfection was the major trigger for TEW and NAW whereas multiple triggers were common of AW, LOW and IOW. Allergens were mostly associated with AW, IOW and LOW. Aeroallergen-specific IgE positivity was mostly with AW, IOW and LOW phenotype. Skin prick tests showed multiple allergen sensitivity in IOW, LOW groups and mostly single allergen in AW phenotype. Modified asthma predictive index (mAPI) positivity was high in all groups except TEW and NAW.Conclusions: With this study we classified five wheeze phenotypes and found that atopy and family s atopy history, maternal asthma were strongly associated with AW, LOW and IOW phenotypes which were usually effected by allergens or multiple triggers.