The efficacy of platinum-based chemotherapy for immune checkpoint inhibitor-resistant advanced melanoma

Abstract

could be a useful biomarker. In addition to these findings, the significant negative linear relationship between baseline NLR and PNI in this study reinforce the importance of nutrition in supporting a healthy immune balance. This is of particular significance in low resource settings where locally advanced cervical cancer is mostly prevalent. Poor nutrition, reflected by a considerable burden of anemia and protein energy malnutrition, is a major health problem in these regions. Consequently, the interaction between nutrition and immune balance and the resulting impact on radiation response assumes particular importance in this scenario. Despite the limited sample size, the findings of this study emphasize on the need for further investigations for determining the strength of the association between NLR and clinical tumor response following chemoradiation in locally advanced cervical cancer. In conclusion, NLR offers an inexpensive yet effective tool in the clinic for alerting the clinician of the possible treatment outcome. A baseline NLR value higher than 5 significantly lowers the clinical complete response, and close monitoring of these women during treatment could offer early and effective salvage in the event of treatment failure.