Acute Response to Capsiate Supplementation at Rest and during Exercise on Energy Intake, Appetite, Metabolism, and Autonomic Function: A Randomized Trial.

Abstract

OBJECTIVE\nThe purpose of the present study was to examine the effect of capsiate supplementation on energy intake, self-reported appetite-related sensations, energy expenditure, fat oxidation, and autonomic parameters with and without an exercise intervention.\n\n\nMETHODS\nThirteen healthy men completed four randomized trials: two trials for the control condition (without exercise), one with capsiate supplementation (CTRLcap) and one with a placebo (CTRLpla), and two trials for the exercise condition, one with capsiate supplementation (EXcap) and one with placebo (EXpla). Exercise sessions were performed 150\u2009min after the consumption of a standardized breakfast, and supplementation 115\u2009min after consumption of breakfast. An ad libitum buffet was offered 200\u2009min following the completion of the standardized breakfast, and energy intake (EI) and relative energy intake (REI) (relative energy intake\u2009=\u2009energy intake - energy expenditure related to exercise) were evaluated.\n\n\nRESULTS\nThere were no significant effects on EI, self-reported appetite sensations, fat oxidation, and energy expenditure. REI was reduced in conditions involving EX when compared to CTRL. A low-frequency to high-frequency ratio for heart rate variability was higher in CTRLcap (1.6\u2009±\u20091.1) vs. CTRLpla (1.2\u2009±\u20090.9) (p\u2009=\u20090.025; d\u2009=\u20090.39).\n\n\nCONCLUSION\nAcute capsiate supplementation combined with aerobic exercise has limited effects on the examined variables (EI, REI, fat oxidation, energy expenditure, and autonomic parameters), while changes in the autonomic nervous system function in the absence of exercise may have occurred without influencing other variables.\n\n\nCLINICAL TRIAL REGISTRATION\nensaiosclinicos.gov.br number, RBR-5pckyr https://ensaiosclinicos.gov.br/rg/RBR-5pckyr.