Effect of two dosages of sodium chloride intake on the blood pressure response to caffeinated coffee in humans in vivo

Abstract

Abstract High sodium intake increases cardiovascular risk by increasing blood pressure. The intake of coffee elevates blood pressure acutely. Preclinical evidence shows that this action of caffeine is enhanced by high salt intake. We hypothesised that high sodium intake augments the acute blood pressure response to coffee in humans. A randomised cross-over study (n\u2009=\u200915) was performed comparing the effect of lower (6\u2009g/d; LS) with higher (12\u2009g/d; HS) sodium chloride diet on blood pressure before and 2\u2009h after regular coffee intake. Baseline blood pressure was 115\u2009±\u20094/84\u2009±\u20092/68\u2009±\u20091 during LS and 121\u2009±\u20094/89\u2009±\u20092/69\u2009±\u20091\u2009mmHg during HS (SBP/Mean Arterial Pressure (MAP)/DBP; mean\u2009±\u2009SE, p\u2009<\u20090.05 for SBP). During LS, blood pressure increased to 121\u2009±\u20094/91\u2009±\u20092/73\u2009±\u20091 (p\u2009<\u20090.05 for SBP, MAP, DBP versus baseline). HS did not significantly affect the impact of coffee on blood pressure (p\u2009>\u20090.3 for SBP, DBP; p\u2009>\u20090.05 for MAP). Sodium intake does not relevantly modulate the impact of regular coffee consumption on blood pressure.