Clinical characteristics and outcomes of black patients with mycosis fungoides and Sézary syndrome: a subgroup analysis of the phase III MAVORIC trial

Abstract

Abstract Treatment-specific responses and comprehensive disease characteristics are limited in black patients with cutaneous T-cell lymphoma (CTCL). These shortcomings prompted us to perform a subgroup analysis of black patients enrolled in the MAVORIC trial – an international, randomized, phase 3 trial comparing mogamulizumab vs. vorinostat in relapsed/refractory mycosis fungoides (MF) and Sézary syndrome (SS). Ten percent (N\u2009=\u200937) of the entire MAVORIC population (N\u2009=\u2009372) identified as black. Significant clinical differences in black patients when compared to non-black patients included a younger median age at enrollment (53 vs. 66\u2009years; p\u2009<\u20090.001), an increased frequency of MF as opposed to SS (73% vs. 52.8%; p\u2009<\u20090.001), and higher rates of earlier-stage disease (IB-IIA) at enrollment (37.8% vs. 21.2%; p\u2009=\u20090.022). Mogamulizumab offered similar response rates and progression-free survival in black patients (7.57\u2009months) compared to the entire MAVORIC population (7.7\u2009months) and was associated with a similar safety profile.