Journal of Macromolecular Science, Part A | 2021
A covalent triazine-based framework containing hydrogen-bonding for highly drug loading and pH-responsive release
Abstract
Abstract A porous covalent triazine-based organic framework (CTF) containing amide hydrogen-bonding was synthesized using Pigment Orange 71 under Lewis acidic (ZnCl2) conditions at 400\u2009°C. The novel CTF material shows excellent chemical and thermal stability with 10% weight loss temperature up to 465\u2009°C and owns a high surface area (960\u2009m2 g−1) and a total pore volume of 0.48\u2009cm3 g−1. The pore size distribution calculated by the non-local density functional theory shows the single micropores center at about 1.5\u2009nm. The CTF particles have an average size of 374\u2009nm and display excellent size-selective adsorption performance, high anticancer drug Irinotecan (CPT-11) loading (27.9\u2009wt%) capacity and outstanding pH-responsive release. Graphical Abstract