The association of von willebrand factor and its cleaving protease (ADAMTS13) with health behaviours in young black and white adults: the African-PREDICT study

Abstract

Abstract To reduce cardiovascular risks imposed by Von Willebrand factor (vWF) and ADAMTS13 from young ages, knowledge on health behaviours that may affect their concentrations is essential. We therefore determined whether circulating vWF antigen and ADAMTS13 associate with health behaviours. We included 1196 black and white healthy adults aged 20-30\u2009years and used questionnaires for socio-economic, tobacco and alcohol use data. vWF:Ag was measured from citrated samples and ADAMTS13, cotinine and gamma-glutamyl transferase (GGT) from serum. Salt intake was estimated from 24-hour urine and body mass index (BMI) was calculated. Black adults had higher vWF:Ag and lower ADAMTS13 levels compared to whites (all p\u2009<\u20090.001). In multiple regression analyses in the total group, vWF:Ag associated positively with BMI (p\u2009=\u20090.037), while ADAMTS13 associated negatively with BMI (p\u2009=\u20090.016) and cotinine (p\u2009=\u20090.029); and positively with GGT (p\u2009=\u20090.002). When exploring within each ethnic group, vWF:Ag associated positively with estimated salt intake (p\u2009=\u20090.043) only in blacks. In whites, vWF:Ag associated positively with BMI (p\u2009=\u20090.023) while ADAMTS13 associated positively with GGT (p\u2009=\u20090.003) and negatively with cotinine (p\u2009=\u20090.041). Young black adults may have an increased thrombotic risk due to higher vWF and lower ADAMTS13. The ethnic-specific associations observed may have implications for public health initiatives to improve cardiovascular outcomes.