Natural product research | 2019
A new monoterpene-lactone with neuroprotective activity from corn silk.
Abstract
A new monoterpene-lactone (1) along with five known compounds (2-6) were isolated from corn silk. The structure of the new compound was elucidated based on comprehensive spectroscopic analyses and quantum chemical calculations of electronic circular dichroism (ECD) curves. All compounds were evaluated for their neuroprotective effects against H2O2-induced damage in human dopaminergic neuroblastoma cells (SH-SY5Y). As a result, compound 1 exhibited weak neuroprotective activity.