Modulation of PTZ-induced convulsions in rats using topiramate alone or combined with low dose gamma irradiation: Involving AKT/m-TOR pathway.

Abstract

CONCLUSIONS\nThe positive effects of LDR could offer a possible contributor in management of convulsions due to modulation of AkT/m-TOR signalling pathway, reduction of oxidative stress and modulation of brain amino acids. LDR improved the oxidative stress side effects of topiramate.HighlightsMale Wistar rats were treated with topiramate 50\u2009mg/kg p.o. for 7 days.on the 6th day of topiramate treatment, rats were exposed to a single low dose whole body gamma radiation (0.5\u2009Gy).on the 7th day of topiramate treatment, rats were injected with pentylenetetrazole 75\u2009mg/kg i.p. 2h after the 7th dose of TOP to illustrate the protective effects of TOP against acute convulsions induced by PTZ.Low dose whole body gamma irradiation purveyed novel anticonvulsant activity which could offer a possible contributor in the basic management of convulsions to avoid side effects of traditional anticonvulsant drugs such as liver and kidney impairments.