Maternal Epilepsy and Umbilical Cord Blood Oxidative Stress Level.

Abstract

INTRODUCTION\nWe investigated the effect of epilepsy on cord blood oxidative stress status.\n\n\nMATERIAL AND METHODS\nThirty (n\u2009=\u200930) pregnant women with epilepsy and thirty (n\u2009=\u200930) healthy controls enrolled in this case control study. Albumin and IMA values and dynamic thiol/disulfide parameters were measured.\n\n\nRESULTS\nDecreased native thiol and total thiol levels were found in the epilepsy group when compared to the control group (p: 0.001, p: 0.002). Higher IMA (p: 0.036) and lower albumin cord levels (P\u2009<\u20090.001) were measured in the epilepsy group with respect to the control group. Apgar scores at 1 and 5\u2009miutes were lower in the epilepsy group (respectively; p\u2009=\u20090.012, p\u2009=\u20090.010). A negative correlation was found between IMA and cord pH value (r\u2009=\u20090.288 p\u2009=\u20090.034).\n\n\nCONCLUSION\nThis study showed that epilepsy may alter thiol disulfide homeostasis and IMA levels.