Predictive value of N-terminal pro-B-type natriuretic peptide (NT-pro BNP) combined with D-dimer for no-reflow phenomenon in patients with acute coronary syndrome after emergency of percutaneous coronary intervention.

Abstract

Acute coronary syndrome (ACS) is a critical illness in cardiovascular disease. The purpose of this study was to investigate the value of N-terminal pro-B-type natriuretic peptide (NT-pro BNP) and D-dimer in predicting the occurrence of no reflow in emergency percutaneous coronary intervention (PCI) in patients with ACS. 168 ACS patients were recruited, including 88 patients with normal reflow and 80 patients with no reflow after emergency of PCI. The levels of serum NT-pro BNP and D-dimer in the patients were detected before PCI, immediately after PCI, 2 hour and 6 months after PCI. ROC curve was used to evaluate the predictive value of NT-pro BNP and D-dimer in no reflow phenomenon. Logistic regression model was used to analyze the independent influencing factors of no reflow phenomenon. Logistic regression analysis confirmed that NT-pro BNP and D-dimer were independent predictors of the occurrence of no reflow in the total population. The ROC curve showed that the AUC value was 0.909 when NT-pro BNP combined with D-dimer. The detection of NT-pro BNP combined with D-dimer was helpful to predict the occurrence of no reflow phenomenon after emergency PCI in ACS patients.