Early Osteogenic Mineral Characteristics In Human Valvular Interstitial Cell Culture - Results of IR-spectroscopy

Abstract

Objective: The main pathological feature of Aortic valve (AV) stenosis is calcification. Molecular pathways leading to mineralization are research focus. The limitations of animal models point out the need for in vitro setups investigating human valvular interstitial cells (hVIC). Project aim is the detailed characterization of hVIC culture mineralization in comparison to AV calcification by IR-spectroscopy and therewith the validation of the in vitro setup for basic research.