Performance of Decellularized and Non-decellularized Cryopreserved Pulmonary Homografts Used for the Reconstruction of the Right Ventricular Outflow Tract in the Ross Procedure: A Comparison

Abstract

Objective: Structural degeneration is the main cause of hemodynamic deterioration and failure of homografts. Immune-mediated processes seem to have a key role. The decellularization of homografts aims to reduce the homografts’ immunogenicity and to improve their performance. The study’s objective was to compare the occurrence of valve-related events and the hemodynamic function of SynerGraft decellularized cryopreserved (CryoLife Inc., Kennesaw, GA, USA) and non-decellularized cryopreserved pulmonary homografts, which were used for right ventricular outflow tract reconstruction in the Ross procedure.