The Journal of Cell Biology | 2019
A molecular recognition feature mediates ribosome-induced SRP-receptor assembly during protein targeting
Abstract
Hwang Fu et al. show that a molecular recognition feature (MoRF) in the mammalian signal recognition particle (SRP) receptor accelerates SRP-receptor assembly in response to the ribosome. The MoRF functionally replaces the bacterial SRP RNA to sense cargo loading and activate cotranslational protein targeting.