CDK1-mediated CENP-C phosphorylation modulates CENP-A binding and mitotic kinetochore localization

Abstract

Kinetochore localization of CENP-C, which is a key and conserved kinetochore component, is regulated during cell cycle progression. Watanabe et al. demonstrate that CDK1-mediated CENP-C phosphorylation regulates mitotic kinetochore localization via binding of CENP-C to the CENP-A nucleosome.