Upregulated LRRC55 promotes BK channel activation and aggravates cell injury in podocytes

Abstract

Podocyte injury is a common hallmark in various glomerular diseases. Upregulated LRRC55 promotes BK channel activation and aggravates podocyte injury in focal segmental glomerulosclerosis, diabetic nephropathy, and membranous nephropathy. LRRC55 inhibition attenuates podocyte injury, thus representing a new therapeutic approach for progressive glomerular disease.