The Journal of Experimental Medicine | 2021
Multimeric antibodies from antigen-specific human IgM+ memory B cells restrict Plasmodium parasites
Abstract
Thouvenel et al. isolate BCR sequences from Plasmodium-specific IgM+ human memory B cells, expressing them as both IgM and IgG molecules. Multimerization confers superior antigen binding and parasite restriction, highlighting an important role for memory B cell–derived IgM in immunity.