Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

Abstract

Human monoclonal antibody potency in vitro does not uniformly correlate with its in vivo neutralization of SARS-CoV-2. Antibody Fc-effector function is important for in vivo neutralization, and antibody combinations show superior efficacy compared with single antibodies.