Polymorphisms of IFN-γ T/A +874 Gene and Relationship with COVID 19 in Iraqi Population

Abstract

This study included 80 blood specimens. Fifty samples collected from COVID 19 with age ranged between 02-75 years, and 30 blood specimens collected from healthy as a control sample with age ranged between 91-63 years. The polymorphism of IFN-γ T/A +874 gene, which amplified by using amplification refractory mutation system (ARMS-PCR) was showed high percentage of A allele frequency in COVID 19 patients sample in comparison with T allele frequency, and the A allele revealed as etiological fraction with risk by having COVID 19 disease, whereas the T allele showed high frequency from the A allele frequency in control specimen, and the A allele revealed as preventive fraction from infection by this disease. The AA and TA genotypes revealed as etiological fraction with risk by having COVID disease, whereas the TT genotype revealed as preventive fraction with risk by having COVID 19 disease. Our findings demonstrate that the IFN-γ Gene T/A +874 gene polymorphism may represent a significant risk factor for COVID 19 in Iraqi population and there is association between the IFN-γ Gene T/A +874 polymorphism and COVID 19 patients.