Relationship Between Cardiovascular Disease (CVD) Risk Factors and Liver Disease Risk Among Participants From the Miami Adult Studies on HIV (MASH) Cohort

Abstract

\n \n \n Cardiovascular disease (CVD) and liver disease risks are higher in people living with HIV (PLWH) than in the general population. We evaluated the association between the Framingham Heart Study (FHS) 10-year CVD risk and noninvasive liver disease indicators in PLWH compared with seronegative individuals.\n \n \n \n Cross-sectional study included adults from the MASH cohort. Demographics, anthropometrics, drug/cigarette use, blood samples (metabolic panel) were collected by trained personnel. HIV status was obtained from medical records with informed consent. CVD risk was estimated using the FHS 10-year risk calculator described at the FHS website. For liver disease risk, 2 indicators were used: FIB-4 (Age, AST, ALT platelet count), and Triglyceride/glucose index (TyG Index). Descriptive statistics and linear regressions analyses were performed, adjusted for BMI, race/ethnicity, drug use/cigarette.\n \n \n \n We analyzed data from 714 adults, of those 339 were PLWH and 375 seronegative. The mean age was 54.28\xa0±\xa07.49 years, 55% were men, 62% were African American and 29% Hispanic. Linear regression showed a direct relationship between FHS score and FIB-4 (b\xa0=\xa00.166; SE\xa0=\xa00.491; CI: 1.170–3.099; P\xa0<\xa00.001). Similar results were found with the FHS score and TyG index (b\xa0=\xa00.323; SE\xa0=\xa00.457; CI: 3.169–4.965; P\xa0<\xa00.001). When stratified by HIV status, similar results were found in PLWH where FHS score was directly related with FIB-4 (b\xa0=\xa00.176; SE\xa0=\xa00.685; CI\xa0=\xa00.906 - 3.602; P\xa0=\xa00.001 in PLWH and the seronegative group b\xa0=\xa00.171; SE\xa0=\xa00.705; CI\xa0=\xa00.857–3.630; P\xa0=\xa00.002, respectively) and TyG Index (b\xa0=\xa00.375; SE\xa0=\xa00.633; CI: 3.291–0.769; P\xa0<\xa00.001 & b\xa0=\xa00.294; SE\xa0=\xa00.668; CI: 2.60–5.23; P\xa0<\xa00.001, respectively).\n \n \n \n Liver disease risk indicators such as FIB-4 and TyG index were associated with a ten-year cardiovascular risk in a predominantly African-American and Hispanic population regardless of HIV infection. These results highlight the need to monitor and address liver disease and CVD risk factors simultaneously in clinical practice.\n \n \n \n National Institute of Drug Abuse – National Institute of Health.\n