The impact of lipid profile in acute coronary syndrome: young patient vs old patient

Abstract

\n \n \n Type of funding sources: None.\n \n \n \n Several studies have suggested a relationship between dyslipidemia and atherogenesis, which displays a main role in the pathophysiology of Acute Coronary Syndrome (ACS).\n \n \n \n To compare the lipid profile between younger (<55 years) and older (≥55 years) patients admitted due to ACS.\n \n \n \n A single-centre retrospective study was conducted, with inclusion of all consecutive patients admitted in the Cardiology Department due to ACS. Several analytical parameters were evaluated, including total cholesterol (CT), HDL cholesterol (HDL), LDL cholesterol (LDL) and triglycerides (TG) and CT/HDL, LDL/HDL and TG/HDL ratios were calculated. All parameters are presented in mg/dL. Afterwards, comparison of these data between younger (age\u2009<\u200955 years, Group-A) and older (age≥55 years, Group-B) patients was done. Statistical analysis was performed with SPSS and a p value < 0.05 was considered statistically significant.\n \n \n \n 1168 patients (70.1% male, mean age 69 ±12 years) were included in this study. 15.8% of patients were from Group-A. Mean levels of the analysed parameters were the following: CT 176\u2009±\u200955, LDL 111\u2009±\u200945, HDL 40\u2009±\u200912 and TG 137\u2009±\u2009102. The following mean ratios were obtained: CT/HDL 4.6\u2009±\u20091.9, LDL/HDL 2.9\u2009±\u20091.4 and TG/HDL 3.8\u2009±\u20093.5. Comparison of the analysed parameters and calculated ratios is exhibited in table 1.\n \n \n \n Overall, a worse lipid profile was observed in younger patients. This data reveals the role of dyslipidemia in coronary heart disease, which displays a main role in atherosclerosis at a younger age. This fact highlights the importance of adopting a healthy lifestyle and the adherence to primary and secondary prevention measures of cardiovascular events.\n Lipid profile: young vs old patient Group A Group B Total Cholesterol 199\u2009±\u200944 170\u2009±\u200956 p\u2009<\u20090.001 LDL Cholesterol 128\u2009±\u200937 107\u2009±\u200946 p\u2009<\u20090.001 HDL Cholesterol 39\u2009±\u200910 40\u2009±\u200912 p\u2009=\u20090.307 Triglycerides 195\u2009±\u2009189 125\u2009±\u200966 p\u2009<\u20090.001 CT/HDL 5.3\u2009±\u20091.5 6.8\u2009±\u20092.0 p\u2009<\u20090.001 LDL/HDL 3.4\u2009±\u20091.1 2.8\u2009±\u20091.4 p\u2009<\u20090.001 TG/HDL 5.6\u2009±\u20096.3 3.5\u2009±\u20092.5 p\u2009<\u20090.001\n