MO673THE ASSOCIATION BETWEEN UREA KINETIC MODELING WITH ANXIETY AND DEPRESSION AMONG PATIENTS ON MAINTENANCE HEMODIALYSIS AT UST HOSPITAL: A CROSS- SECTIONAL STUDY

Abstract

\n \n \n Depression and anxiety are common psychiatric disorders that affect patients with chronic kidney disease on maintenance hemodialysis. Possible explanation for the development of this mental disorders includes physical and emotional stress, time restrictions, functional limitations, co-morbidities, adverse effects of medications and lack of adherence to dialysis treatment and its efficacy. Studies have shown that by improving hemodialysis adequacy, as measured by the urea kinetic remodelling (Kt/V), the clinical symptoms of the patient improve as well as their psychological condition. This study aimed to evaluate the relationship between psychological symptoms and hemodialysis adequacy.\n \n \n \n This cross-sectional study was conducted on 87 hemodialysis patients at the University of Santo Tomas Hospital. Anxiety and depression was assessed using the validated Filipino version of Hospital Anxiety and Depression scale (HADS-P). Anxiety and depression was defined as score of 8. Descriptive statistics were used to summarize the general and clinical characteristics of the participants. Frequency counts and proportions were used as descriptors for nominal variables, median and range for ordinal variables, and mean and standard deviation for interval/ratio variables. Chi square test was used to assess the association between age, sex, marital status, duration of dialysis and Kt/V.\n \n \n \n The prevalence of anxiety and depression were 34.8% and 21.7%, respectively (n=87). This study identified that younger patients, those belonging to age 20-35 y/o were more depressed (33.3%) and anxious (66.7%). Similarly, females also tend to be more anxious (42.5%) and depressed (22.5%). On the other hand, single patients tend to be more anxious (41.7%) while married are more depressed (22.8%). As to educational status, post graduate patients were more anxious (66.7%) and those with low educational attainment were more depressed (50%). Newly initiated patients (<1 year) were more anxious (57.1%) and those with longer years on hemodialysis (4-6 years) being more depressed (30.4%). As to laboratory parameters, anemic patients are both anxious and depressed. Hypoalbuminemic patients were also anxious and depressed. Patients with adequate hemodialysis were more anxious and depressed.\n \n \n \n Anxiety and depression are common psychiatric disorder that are associated with decrease quality of life. Addressing and including these conditions will help to improve their psychological condition.\n